We have uploaded comprehensive and high-resolution ATAC-seq, ChIP-seq, and RNA-seq datasets regarding Young and Old murine HSC studies. Currently, the manuscript is in preparation with additional functional assays targeting a couple of genes we identified. Le Zong, Bongsoo Park, Isabel Beerman 2013 Manuscript in preparation.
We uploaded supplementary tables for mouse and human DEGs. For human HSC aging study, we used datasets published in Cancer Discovery (Adelman et al, Cancer Discovery 2019). We downloaded raw datasets and performed transcriptome analysis. You can click the result file > download. Human DEGs (Old vs. Young) Mouse DEGs (Old vs. Young)
Bivalent chromatin is a segment of DNA, bound to histone proteins that have both repressing and activating epigenetic marks in the same region. Explicitly at bivalent promoters, with the presence of both H3K27me3 (repressive marks) and K3K4me3 (activating marks), almost twenty percent of domains had significant age-associated alterations with almost half of the modified bivalent promoters…