HSC Bivalent promoters

Bivalent chromatin is a segment of DNA, bound to histone proteins that have both repressing and activating epigenetic marks in the same region. Explicitly at bivalent promoters, with the presence of both H3K27me3 (repressive marks) and K3K4me3 (activating marks), almost twenty percent of domains had significant age-associated alterations with almost half of the modified bivalent promoters associated with HSC transcriptional alterations. These histone modification changes were accompanied by an overall more open chromatin landscape allowing for increased accessibility at functionally relevant transcription factor binding sites and aberrant expression of transposable elements in aged HSCs. Here, we performed Bivalent promoter analysis using Histone ChIP-seq datasets (H3K27me3, H3K4me3). We also visualized in scatter plots the fold changes of histone modification between Old HSCs and Young HSCs.

1. Human Bivalent promoters
2. Mouse Bivalent promoters
3. Comparison between mouse and human